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If you’re craving a dish that brings bold flavors together in the creamiest, most indulgent way, look no further than this Creamy Velveeta Penne Pasta with Cajun Beef Alfredo Sauce Recipe. It’s the perfect marriage of tender penne pasta bathed in a rich, cheesy sauce, spiced just right with Cajun seasoning, and loaded with juicy ground beef and sweet red bell peppers. Every bite sings with warmth and comfort, making it a guaranteed crowd-pleaser whether it’s a busy weeknight or a special gathering with friends.

Ingredients You’ll Need
These ingredients might look straightforward, but each one plays an essential role in building layers of flavor, texture, and color in your dish. From the creamy Velveeta to the pop of red bell peppers, every component is a small star that helps create a big, irresistible flavor.
- 1 pound penne pasta: Perfectly shaped to catch and hold that luscious sauce in every bite.
- 1 pound ground beef: Adds hearty substance and a savory base for the Cajun seasonings to shine.
- 1 cup diced red bell peppers: Brings a subtle sweetness and vibrant color to the dish.
- 8 ounces Velveeta cheese, cubed: The secret to a silky, smooth sauce that clings to pasta beautifully.
- 1 cup heavy cream: Deepens the richness, making the sauce decadently creamy without overpowering the spice.
- 2 teaspoons Cajun seasoning: Provides that signature spicy kick with a blend of herbs and spices.
- 1 teaspoon garlic powder: Enhances the savory notes and complements the beef perfectly.
- 1 teaspoon onion powder: Adds a mild sweetness and depth without needing fresh onions.
- 1 cup shredded mozzarella cheese: Optional but highly recommended for a golden, bubbly topping.
- 1 tablespoon chopped parsley (optional): A fresh burst of color and a mild herbal finish.
- Salt and black pepper to taste: Essential seasonings that bring all the flavors into balance.
How to Make Creamy Velveeta Penne Pasta with Cajun Beef Alfredo Sauce Recipe
Step 1: Cook the Penne Pasta
Start by bringing a large pot of salted water to a rolling boil. Cooking your penne pasta just until al dente is key—it should be tender yet still have a slight bite to provide a perfect contrast to the creamy sauce. Drain it well and set aside so it’s ready to soak up all the rich flavors in the next steps.
Step 2: Brown the Cajun-Spiced Ground Beef
Heat a large skillet over medium-high and add your ground beef, breaking it apart gently as it cooks. Once the beef is nicely browned, drain off excess fat. Then, stir in your mix of Cajun seasoning, garlic powder, and onion powder. This spice combo transforms the meat into a robust centerpiece that builds excitement for the dish ahead.
Step 3: Sauté the Red Bell Peppers
Add the diced red bell peppers to the skillet and cook them for about 3 to 4 minutes. This step softens their texture while preserving a slight crunch and sweet pop of freshness that beautifully balances the richness of the sauce and beef.
Step 4: Create the Velvety Alfredo Sauce
Turn the heat down to medium-low and pour in the heavy cream, stirring it around to deglaze the skillet and scrape up any flavorful bits stuck to the pan. Then add the Velveeta cheese cubes and stir continuously until melted into a luxuriously smooth sauce. This is where the dish really earns its “creamy” title.
Step 5: Combine Pasta and Sauce
Toss the cooked penne into the skillet, making sure every piece gets fully coated with the luscious Velveeta Alfredo sauce. Take a moment to taste and adjust the salt and pepper to your liking—this is your chance to perfect that flavorful balance.
Step 6: Optional: Add a Cheesy Broiled Top
If you’re in the mood for an extra layer of indulgence, transfer everything into a baking dish and sprinkle the shredded mozzarella cheese evenly on top. Broil just long enough—about 2 to 3 minutes—until the cheese bubbles and turns golden brown. This step adds an irresistible crusty finish that brings a gourmet touch to the dish.
Step 7: Garnish and Serve Hot
Sprinkle freshly chopped parsley over the pasta for a bright, fresh note and that inviting pop of green color. Serve your dish right away to enjoy it at its creamiest and most comforting.
How to Serve Creamy Velveeta Penne Pasta with Cajun Beef Alfredo Sauce Recipe
Garnishes
Fresh parsley is a classic finishing touch, adding color and a mild herbal brightness that balances the richness. For a little extra zing, a sprinkle of crushed red pepper flakes or a squeeze of fresh lemon juice can awaken the flavors beautifully.
Side Dishes
This dish pairs wonderfully with simple sides that don’t compete with its boldness. Think a crisp green salad with a tangy vinaigrette, garlic bread to mop up every bit of sauce, or roasted vegetables like asparagus or broccoli to introduce some fresh texture.
Creative Ways to Present
For a fun twist, serve the pasta in shallow bowls topped with a sprinkle of extra Cajun seasoning or chopped green onions. You could also layer it in individual ramekins and broil the mozzarella topping for individual cheesy crusts. Presentation makes it feel extra special for a dinner party.
Make Ahead and Storage
Storing Leftovers
If you have any leftovers from your Creamy Velveeta Penne Pasta with Cajun Beef Alfredo Sauce Recipe, store them in an airtight container in the refrigerator. It will keep well for up to 3 days, though the dish is so delicious, you might find it hard to resist finishing it sooner!
Freezing
This pasta freezes well if you want to prep ahead or save portions. Divide into freezer-safe containers and freeze for up to 2 months. When ready to eat, thaw overnight in the fridge for best results.
Reheating
To reheat, warm the pasta gently in a covered skillet or microwave, adding a splash of cream or milk to bring back the creamy texture. Stir frequently to keep the sauce silky and prevent it from drying out or separating.
FAQs
Can I use a different type of pasta instead of penne?
Absolutely! While penne holds the sauce beautifully thanks to its tube shape, rigatoni, rotini, or even fettuccine would also work great and give you a slightly different texture experience.
Is Velveeta necessary, or can I substitute with another cheese?
Velveeta is what gives the sauce that signature creamy smoothness and melt. However, you can substitute with processed cheese or add a blend of cream cheese and sharp cheddar to replicate the texture and flavor, though the consistency might vary.
How spicy is this dish with the Cajun seasoning?
The Cajun seasoning provides a mild to moderate kick balanced by the creamy sauce. You can adjust the amount to your taste, or add extra crushed red pepper flakes if you like it hotter.
Can I make this recipe vegetarian?
Yes! Simply swap the ground beef for sautéed mushrooms, diced zucchini, or a plant-based meat substitute to keep the same texture and heartiness without the meat.
What if I don’t have heavy cream on hand?
You can substitute half-and-half or whole milk mixed with a bit of butter to mimic the richness, though the sauce may be slightly less thick and creamy. Just heat gently to avoid curdling.
Final Thoughts
This Creamy Velveeta Penne Pasta with Cajun Beef Alfredo Sauce Recipe is truly a comfort food masterpiece that never fails to impress. With its irresistible combination of cheesy indulgence and spicy Cajun flair, it’s bound to become a fast favorite in your recipe rotation. So go ahead, dive in and enjoy every savory, creamy bite—you won’t regret it!
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Creamy Velveeta Penne Pasta with Cajun Beef Alfredo Sauce Recipe
- Prep Time: 10 minutes
- Cook Time: 25 minutes
- Total Time: 35 minutes
- Yield: 6 servings
- Category: Main Course
- Method: Stovetop
- Cuisine: American
Description
This Creamy Velveeta Penne Pasta with Cajun Beef Alfredo Sauce combines tender penne pasta with a rich, cheesy Velveeta and heavy cream sauce, enhanced by savory ground beef and vibrant red bell peppers. Seasoned with Cajun spices and garlic, this dish delivers a comforting, flavorful meal perfect for family dinners or casual gatherings.
Ingredients
Pasta
- 1 pound penne pasta
Beef and Vegetables
- 1 pound ground beef
- 1 cup diced red bell peppers
Sauce
- 8 ounces Velveeta cheese, cubed
- 1 cup heavy cream
- 2 teaspoons Cajun seasoning
- 1 teaspoon garlic powder
- 1 teaspoon onion powder
Toppings and Garnishes
- 1 cup shredded mozzarella cheese
- 1 tablespoon chopped parsley (optional)
- Salt and black pepper to taste
Instructions
- Cook Pasta: Bring a large pot of salted water to a boil. Add the penne pasta and cook until al dente according to package directions. Drain the pasta and set it aside for later use.
- Brown Ground Beef: Heat a large skillet over medium-high heat. Add the ground beef and cook, breaking it apart frequently, until browned and cooked through. Drain any excess fat from the skillet. Season the beef with Cajun seasoning, garlic powder, and onion powder, stirring to evenly coat.
- Sauté Bell Peppers: Add the diced red bell peppers to the skillet with the seasoned beef. Sauté for 3 to 4 minutes until the peppers are slightly softened and fragrant.
- Make Cheese Sauce: Reduce the heat to medium-low. Pour the heavy cream into the skillet, stirring to deglaze and lift any browned bits off the bottom. Add the cubed Velveeta cheese and stir continuously until the cheese has fully melted into a smooth, creamy sauce.
- Combine Pasta and Sauce: Add the drained penne pasta into the skillet and toss everything together so the pasta is well coated with the creamy Velveeta Cajun sauce. Taste and adjust seasoning with salt and black pepper as needed.
- Optional Broil with Mozzarella: For a golden, bubbly top, transfer the skillet mixture into a baking dish. Sprinkle the shredded mozzarella cheese evenly over the top. Place under a broiler for 2 to 3 minutes until the cheese is melted, golden, and bubbly. Watch carefully to avoid burning.
- Serve and Garnish: Garnish the finished dish with chopped parsley if desired. Serve hot and enjoy this comforting and cheesy Cajun-inspired pasta meal.
Notes
- You can substitute rotini or rigatoni for penne pasta if preferred.
- For added heat, sprinkle extra Cajun seasoning or a pinch of cayenne pepper.
- Make sure to watch the dish closely while broiling to prevent burning the cheese topping.
- Leftovers can be stored in the refrigerator for up to 3 days and reheated gently on the stovetop or microwave.
- To reduce fat, you can substitute half-and-half for heavy cream or use lean ground beef.

